Z01 SC 010353 (Z01) | |||
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Title | Experimental Therapeutics of Pediatric Hematopoietic Malignancies | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Wayne, Alan | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $350,571 | Project Dates | 10/01/2000 - N/A |
Fiscal Year | 2007 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Bone Marrow Transplantation (50.0%) Chemotherapy (50.0%) Childhood Cancers (75.0%) MOAB (50.0%) |
Childhood Leukemia (75.0%) Hodgkins Disease (25.0%) Leukemia (75.0%) Non Hodgkins Lymphoma (25.0%) |
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Research Type | |||
Systemic Therapies - Discovery and Development Systemic Therapies - Clinical Applications |
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Abstract | |||
The primary goal is to develop new treatments for childhood leukemias and lymphomas. The following projects are currently underway or in preparation: 1) Pilot Study of Non-Myeloablative, HLA-Matched Allogeneic Stem Cell Transplantation in Pediatric Leukemias and Lymphomas 2) Anti-CD22 Immunotoxin for Treatment of Leukemias and Lymphomas in Childhood 3) Unconjugated Monoclonal Antibodies for Treatment Lymphomas In Childhood 4) EPOCH-Rituximab for HIV-Associated Non-Hodgkin's Lymphomas In Childhood 5) Phase II Study of UCN-01 In Relapsed Or Refractory Systemic Anaplastic Large Cell And Mature T-Cell Lymphomas 6) Bench-to-Bedside Translational Development of WT1 Peptide-Transduced Allogeneic Dendritic Cell Vaccine for Childhood ALL 7) Hematologic Malignancy Biology Study 9) Comparative Oncology Investigations in Dogs as Model for Translational Studies in Pediatric Non-Hodgkin's Lymphomas |